Cell Biology

Cancer Biology and the Nuclear Envelope: Recent Advances May by Eric C. Schirmer,Jose I. de las Heras

By Eric C. Schirmer,Jose I. de las Heras

"Nuclear envelope (NE) defects were associated with melanoma biology because the mid-1800s, however it was once now not till the previous few years that we have got started to appreciate those old hyperlinks and to gain that there are myriad ways in which the NE affects on tumorigenesis. The NE  is a fancy double membrane method that encloses the genome whereas delivering structural aid in the course of the intermediate filament lamin polymer and regulating protein/ mRNA trafficking and signaling among the nucleus and cytoplasm through the nuclear pore complexes (NPCs). those capabilities already offer a few mechanisms for NE affects on melanoma biology yet paintings some time past few years has elucidated many others. Lamins and plenty of lately pointed out NE transmembrane proteins (NETs) were now proven to operate in DNA fix, rules of phone cycle and signaling, apoptosis, phone migration in metastasis and nuclear structure and morphology. This quantity offers a complete evaluation of the wide variety of capabilities lately pointed out for NE proteins and their relevance in melanoma biology, delivering molecular mechanisms and proof in their worth as prognostic and diagnostic markers and suggesting new avenues for the remedy of melanoma. certainly a few of these contemporary hyperlinks are already yielding promising treatments, resembling the present scientific trial of selective inhibitors of the nuclear export issue exportin in specific sorts of leukemia, cancer and kidney cancer."

Show description

Read Online or Download Cancer Biology and the Nuclear Envelope: Recent Advances May Elucidate Past Paradoxes: 773 (Advances in Experimental Medicine and Biology) PDF

Similar cell biology books

Functional Ultrastructure: An Atlas of Tissue Biology and Pathology

This atlas of practical ultrastructure offers not just an in depth perception into the advanced constitution and association of cells and tissues but in addition into particular features fulfilled by way of some of the mobile organelles and the dynamics of different procedures inside of cells. the big choice of electron micrographs, including these from immunoelectron microscopy, is complemented through thorough explanatory texts and schemes.

Receptor Tyrosine Kinases: Structure, Functions and Role in Human Disease

Receptor Tyrosine Kinase: constitution, services and position in Human sickness, for the 1st time, systematically covers the shared structural and practical beneficial properties of the RTK kinfolk. Receptor Tyrosine Kinases (RTKs) play severe roles in embryogenesis, basic body structure and several other ailments. And over the past decade they've got develop into the number one goals of melanoma medications.

Advances in Cell Culture: 7

Advances in telephone tradition, quantity 7 is a compilation of study papers within the box of mobilephone tradition. The contributions mirror the purposes of in vitro options of phone tradition to biotechnology, reviewing the benefits and drawbacks of the tools. This quantity covers the cultivation of fish and crustacean cells; gene move in insect cells; and the research of bacterial protein pollution utilizing vertebrate cells.

Molecular and Cellular Biology of Platelet Formation: Implications in Health and Disease

This booklet offers a complete perception into platelet biogenesis, platelet sign transduction, involvement of platelets in disorder, using various animal versions for platelet examine and destiny views in regard to platelet creation and gene remedy. Being written by way of foreign specialists, the book is a concise state-of-the art work within the box of platelet biogenesis, biology and learn.

Additional info for Cancer Biology and the Nuclear Envelope: Recent Advances May Elucidate Past Paradoxes: 773 (Advances in Experimental Medicine and Biology)

Example text

Download PDF sample

Rated 4.13 of 5 – based on 47 votes